pH-sensitive drug controlled release core/shell fibers fabricated by combination of electrospinning and photopolymerization

Xiaolei Zhu; Hongwei Zhang; Jun Nie; Guiping Ma

Journal of Industrial and Engineering Chemistry, Vol.45, 334-337, January, 2017

DOI10.1016/j.jiec.2016.09.045 Export Citation

pH-sensitive drug controlled release core/shell fibers fabricated by combination of electrospinning and photopolymerization

Xiaolei Zhu, Hongwei Zhang, Jun Nie, and Guiping Ma^†

Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, PR China

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pH-sensitive drug loaded core shell fibers were fabricated by a combination of electrospinning and UV photo-polymerization. Combretastatin A4 (CA4) was selected as the model drug loaded in PLA to test the pH-sensitivity property of the core shell fibers. The morphology of the fibers was studied by scanning electron microscopy (SEM), and the core shell structure of the fibers was confirmed by transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS). The drug release assay was tested via the UV-vis spectrophotometer, and the pH-sensitivity of core shell fibers was tested by drug release assay under pH 5.0 and 7.4.

Keywords:Electrospinning;Photo-polymerization;Core shell fibers

[References]

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Chen J, Ouyang J, Kong JM, Zhong W, Xing MM, ACS Appl. Mater. Interfaces, 5, 3108 (2013)

[Referenced By]

[1] Reneker DH, Yarin AL, Polymer, 49(10), 2387 (2008)

[2] Sill TJ, Recum HA, Biomaterials, 29, 1989 (2008)

[3] Luo X, Zheng X, Wang D, Zhang Y, Cheng H, Wang X, Zhuang H, Lou Y, Sens. Actuators B-Chem., 202, 1010 (2014)

[4] Cestari M, Muller V, Rodrigues JHD, Nakamura CV, Rubira AF, Muniz EC, Biomacromolecules, 15(5), 1762 (2014)

[5] Li XH, Zhang YC, Li HY, Chen HB, Ding YM, Yang WM, Desalination, 344, 266 (2014)

[6] Pant HR, Neupane MP, Pant B, Panthi G, Oh HJ, Lee MH, Kim HY, Colloids Surf. B: Biointerfaces, 88, 587 (2011)

[7] Im JS, Lee SK, Bai BC, Lee YS, J. Ind. Eng. Chem., 18(1), 325 (2012)

[8] Liu J, Huang YR, Kumar A, Tan A, Jin SB, Mozhi A, Liang XJ, Biotechnol. Adv., 32(4), 693 (2014)

[9] Sohrabi A, Shaibani PM, Etayash H, Kaur K, Thundat T, Polymer, 54(11), 2699 (2013)

[10] Amin MS, Abolghasem STS, Maryam HM, Ahmad MS, Sci. China Chem., 57, 857 (2014)

[11] Sun XY, Zhou YF, Yan DY, Sci. China Ser. B: Chem., 52, 1703 (2009)

[12] Nie SY, Lin WJ, Yao N, Guo XD, Zhang LJ, ACS Appl. Mater. Interfaces, 6, 17668 (2014)

[13] Xu J, Jiao Y, Shao X, Zhou C, Mater. Lett., 65, 2800 (2011)

[14] Yu H, Jia YT, Chen GZ, Zhang YM, Mater. Lett., 164, 505 (2016)

[15] Zhang HW, Niu QJ, Wang N, Nie J, Ma GP, Eur. Polym. J., 71, 440 (2015)

[16] Li Y, Lim CT, Kotaki M, Polymer, 56, 572 (2015)

[17] Chen J, Ouyang J, Kong JM, Zhong W, Xing MM, ACS Appl. Mater. Interfaces, 5, 3108 (2013)