마이크론 이하 단위의 제품생산 최적화를 위한 화학공정의 스케일업

정영미; Young Mi Chung

Applied Chemistry for Engineering, Vol.28, No.1, 17-22, February, 2017

DOI10.14478/ace.2016.1127 Export Citation

마이크론 이하 단위의 제품생산 최적화를 위한 화학공정의 스케일업

Scale-up of Optimized Chemical Processes for Micron and Submicron Products

정영미

한국기술교육대학교 에너지신소재화학공학부

Young Mi Chung

Korea University of Technology and Education, School of Energy, Materials & Chemical Engineering, 1600, Chungjeol-ro, Byeongcheon-myeon, Dongnam-gu, Cheonan-si, Chungcheongnam-do 31253, Republic of Korea

초록

본 총설에서는 마이크론 사이즈 이하 제품에 대한 최적화적인 화학공정의 스케일업을 위한 전략을 소개한다. 최적화된 화학공정의 스케일업을 위해 구해야 할 스케일업 인자의 정의와 이를 도출하는 방법을 소개하였으며, 특히 무반응시스템, 유반응 시스템으로 분류하여 각각에 대해 서로 다른 스케일업 인자를 찾은 기준을 소개하고, 예시를 들어논의하였다. 본지에서 소개된 스케일업 인자를 구하는 방법론이 마이크론 사이즈 이하 제품에 대한 화학공정을 스케일업하고자 하는 엔지니어들에게 초기 지침서가 될 것으로 기대된다.

This review deals with scale-up strategies for optimized chemical processes particularly for micron and submicron products. The method of finding scale-up factors was also introduced for two systems, a system with chemical reaction and a system without chemical reaction. This review is expected to serve as an initial guideline for process engineers who are to scale up their current chemical processes for small products of micron or submicron size.

Keywords:scale-up;scale-up factor;dimensionless number;Damkoehler number

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[1] Matsen JM, Powder Technol., 88(3), 237 (1996)

[2] Perrut M, Clavier JY, Ind. Eng. Chem. Res., 42(25), 6375 (2003)

[3] Weuster-Botz D, Hekmat D, Puskeiler R, Franco-Lara E, Adv. Biochem. Eng. Biotechnol., 105, 205 (2007)

[4] He LZ, Sun Y, Bioprocess. Biosyst. Eng., 25, 155 (2002)

[5] Lonsane BK, Saucedo-Castaneda G, Raimbault M, Roussos S, Viniegra-Gonzalez G, Ghildyal NP, Ramakrishna M, Krishnaiah MM, Process Biochem., 27, 259 (1992)

[6] Kamiya T, Kaminoyama M, Nishi K, Misumi R, J. Chem. Eng. Jpn., 43(4), 326 (2010)

[7] Atiemo-Obeng VA, Calabrese RV, Handbook of Industrial Mixing: Science and Practice, John Wiley & Sons, Hoboken, USA, 470-505 (2004).

[8] Davies JT, Chem. Eng. Sci., 40, 839 (1985)

[9] Davies JT, Chem. Eng. Sci., 42, 1671 (1987)

[10] Sumi Y, Kamiwano M, Production method for objective size of suspension droplet in different scale of mixing devices, Japanese Patent 066284 (2002).

[11] Maa YF, Hsu C, J. Control. Release, 38, 219 (1996)

[12] Barailler F, Heniche M, Tanguy PA, Chem. Eng. Sci., 61(9), 2888 (2006)

[13] Calabrese RV, Francis MK, Mishra VP, Phongikaroon S, Measurement and analysis of drop size in batch rotor- stator mixer, Proceedings of 10th European Conference on Mixing, July 2-5, Delft, Netherlands (2000).

[14] Hielscher T, Ultrasonic production of nano-size dispersions and emulsions, Dans European Nano Systems Worshop - ENS 2005, Dec. 14-16, Paris, France (2005).

[15] Sole I, Pey CM, Maestro A, Gonzalez C, Porras M, Solans C, Gutierrez JM, J. Colloid Interface Sci., 344(2), 417 (2010)

[16] Paul E, Treybal RE, AIChE J., 17, 718 (1971)

[17] Ogbonna JC, Mashima H, Tanaka H, Bioresour. Technol., 76(1), 1 (2001)

[18] Philippe R, Serp P, Kalck P, Kihn Y, Bordere S, Plee D, Gaillard P, Bernard D, Caussat B, AIChE J., 55(2), 450 (2009)

[19] Romero JB, Johanson LN, Chem. Eng. Prog. Symp. Ser., 58, 28 (1962)

[20] Knowlton TM, Karri SBR, Issangya A, Powder Technol., 150(2), 72 (2005)

[21] Broadhurst TE, Becker HA, AIChE J., 21, 238 (1975)

[22] Glicksman LR, Chem. Eng. Sci., 39, 1373 (1984)

[23] van Ommen JR, Teuling M, Nijenhuis J, van Wachem BGM, Powder Technol., 163(1-2), 32 (2006)

[24] Sierra C, Bonniol F, Occelli R, Tadrist L, Chem. Eng. Sci., 64(16), 3717 (2009)

[25] Sanderson J, Rhodes M, AIChE J., 51(10), 2686 (2005)

[26] Marchisio DL, Rivautella L, Barresi AA, AIChE J., 52(5), 1877 (2006)

[27] Tissot S, Farhat M, Hacker DL, Anderlei T, Kuhner M, Comninellis C, Wurm F, Biochem. Eng. J., 52, 181 (2010)

[28] Garcia-Ochoa F, Gomez E, Biotechnol. Adv., 27, 153 (2009)

[29] Gamboa-Suasnavart R, Marin-Palacio L, Marinez-Sotelo JA, Espitia, Servin-Gonzalez CL, Valdez-Cruz NA, Trujillo-Roldan MA, World J. Microbiol. Biotechnol., 29, 1421 (2013)