Synthesis of methoxy poly(ethylene glycol)-b-poly(DL-lactide-coglycolide) copolymer via diselenide linkage and fabrication of ebselen-incorporated nanoparticles for radio-responsive drug delivery

Changyong Choi; Hyo Young Lee; Young-Il Jeong; Jae-Woon Nah

Journal of Industrial and Engineering Chemistry, Vol.47, 112-120, March, 2017

DOI10.1016/j.jiec.2016.11.021 Export Citation

Synthesis of methoxy poly(ethylene glycol)-b-poly(DL-lactide-coglycolide) copolymer via diselenide linkage and fabrication of ebselen-incorporated nanoparticles for radio-responsive drug delivery

Changyong Choi, Hyo Young Lee¹, Young-Il Jeong^{2, †}, and Jae-Woon Nah^†

Department of Polymer Science and Engineering, Sunchon National University, Jeonnam 57922, Republic of Korea
¹Radiological Science, Dong-Eui University, Pusan 47340, Republic of Korea
²Biomedical Research Institute, Pusan National University Hospital, Pusan 49241, Republic of Korea

E-mail:,

The ebselen has radio-protective effect. In this study, we investigate radio-protective effect of ebselenincorporated nanoparticles using methoxy poly(ethylene glycol)-b-poly(DL-lactide-co-glycolide) copoly-mer (LEsese). Ebselen-incorporated LEses nanoparticles were fabricated by nanoprecipitation and dialysis method. Their radio-protective effect was assessed under irradiation conditions in vitro and in vivo. The diameter was around 100 nm with spherical shapes. The ebselen release from nanoparticles was accelerated by irradiation dose. It compensated radiation damage against cells. Especially, ebselenincorporated nanoparticles have superior radio-protective effects against animal’s whole body irradiation trials. We suggest that LEsese nanoparticles are good candidate for radiation-responsive drug delivery and radioprotection application.

Keywords:Radiosensitive;Block copolymer;Ebselen;Nanoparticles;Radioprotection

[References]

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