The present report covers the investigation of three-dimensional MHD nanofluid flow over a slendering (variable thickness) stretching sheet bearing thermophoresis, Brownian motion and slip effects. For this investigation, we considered water based Cu and CuO nanofluids. With the assistance of similarity transformations, we changed the derived governed equations as ordinary differential equations. The mathematical results determined by employing Runge-Kutta and Newton's methods. We exhibit and explain the graphs for various parameters of interest. We discussed the skin friction coefficient, reduced Nusselt and reduced Sherwood numbers for the influence of the pertinent parameters with the assistance of tables separately for two nanofluids. (Cu-water and CuO-water). Results are validated by comparing with the published results and found a favorable agreement. (C) 2016 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.