Transformation of the energy sector's power generation mix is needed to contain global mean temperature rise to no more than 2 degrees C above the pre-industrial level. Because the power sector is also a dominant direct and indirect consumer of water, it is vital to understand current and likely future trends in power sector water consumption. In this paper, we use an input-output based hybrid approach to study the direct and indirect impacts on water consumption from power mix adjustment in the world's seven largest emitting economies under multiple cost-effective mitigation pathways toward the 2 degrees C target. Although different pathways exist, we discovered generally increases in water consumption of power sector under the long-term 2 degrees C target compared with no-climate-policy pathways, especially for China and India. Fulfilling the Intended National Determined Contributions (INDCs) could decouple direct water consumption and electricity output for most regions but may result in increases of indirect water consumption in China. This paper suggests that in the light of geographically uneven water scarcity, more comprehensive evaluation of both the direct and indirect water demands of the power sector is demanded when considering climate policies relevant to significant structural and technological adjustments in power sector. (C) 2016 Elsevier Ltd. All rights reserved.