In this work, an experimental fault tolerant control (FTC) implementation is presented. The FTC is based on a multi-input multi-output (MIMO) model predictive control (MPC). The aim of the FTC is to keep on operating a double-pipe counter-current heat exchanger even if the main actuator of the heat exchanger is stuck open. To develop the FTC, an adaptive observer was implemented in order to design a fault detection and isolation (FDI) system. In the FDI system, the cold and hot water flow rate estimations by the adaptive observer are compared to the control signals provided by the MPC. The results of the implementation of the FTC using a MIMO model predictive control were compared to the results obtained in a previous work which was developed using model-following control.