Solid SnF2 was able to catalyze the glycerol ketalization with propanone giving solketal (i.e. 2,2-dimethyl-1,3-dioxolane-4-methanol) in reactions with high conversions and regioselectivity (ca. 97%). Tin(II) fluoride is commercially available, water tolerant and less corrosive solid Lewis acid catalyst. Herein, we have described an alternative process to the Bronsted acid-catalyzed reactions in homogeneous phase, where the product neutralization steps are avoided, and the catalyst is easily recovered and reused without loss activity. In addition to develop a catalytic system, the process engineering including the definition of basic equipment for economic evaluation was too investigated. A process flow diagram (PFD) was developed to generate the most favorable operating conditions for solketal production through SnF2-catalyzed glycerol condensation with propanone. We used the UNISim (TM) software to perform the material and energy balances. The plant could work with 432 t/y of glycerol and could produce 620.9 t/y of solketal. The solketal cost was 12.29 $ (USD)/kg. This analysis suggests that solketal production from glycerol deserves serious consideration by the'investors. (C) 2016 Elsevier B.V. All rights reserved.