Three-dimensional Ti-Sn/gamma-Al2O3 particle electrodes were prepared for the efficient degradation of chloramphenicol (CAP) in wastewater. To observe the surface morphology and structural characteristics of the Ti-Sn/gamma-Al2O3 particle electrodes, Fourier transform infrared spectroscopy, X-ray fluorescence, scanning electron microscopy, and X-ray diffraction were used for characterization. Parameters affecting the degradation efficiency and energy consumption of the Ti-Sn/gamma-Al2O3 particle electrodes, such as conductivity, initial pH of wastewater, current density, air flow, and initial CAP concentration (100 mg center dot L-1), were examined. Results showed that the optimal conditions were 0.1 A current intensity, 1.0 L center dot min(-1) air flow, 6000 mu S center dot cm(-1) conductivity, and pH 6. More than 70% of CAP was degraded under the optimal conditions. Based on the reaction intermediate products identified, a possible pathway for the electrochemical oxidation of CAP by the Ti-Sn/gamma-Al2O3 particle electrodes was proposed. (C) 2016 Elsevier B.V. All rights reserved.