This work offers an extensive framework for the techno-economic evaluation of the subsurface and surface components of low-grade geothermal (<100 degrees C) desalination systems, that is based on validated hydrogeological, thermodynamic, and economic considerations. Additionally, this work incorporates a recently developed advanced multi-effect distillation (MED) process for an improved utilisation of the geothermal heat sources. The analysis focuses on a pre-feasibility study for Western Australia, the influence of the different cost drivers, especially the often overlooked geothermal well field parameters like permeability, So as to permit rational assessments of potential application sites. For the surveyed area in Western Australia, the confluence of geothermal and desalination systems results in a promising and economically viable alternative water source. (C) 2016 Elsevier B.V. All rights reserved.