The main purpose of ventilation systems is to satisfy the need of occupants in terms of thermal comfort and air quality. In the case of mixing ventilation, based on the use of jets from one or from multiple diffusers placed in the room, the fresh air and the thermal loads should be distributed in the entire occupied zone. Therefore, the design of the diffusers must aim, beyond aesthetic aspect, the ability to provide a good mixing between the jet and the ambient air. Enhancement of jet induction by means of lobed inserts into a diffuser, was recently proposed in an European patent as a promising and low-cost solution for improving the performance of HVAC systems. In this paper, an experimental investigation on jet characteristics and thermal comfort generated by a classical multi-cone ceiling-mounted diffuser is proposed. Its performance is compared with the same diffuser equipped with lobed inserts. A simplified heated manikin simulates the presence of a human body in the test room. Airflow pattern from the diffuser and its interaction with the manikin were analyzed with whole-field PIV technique. Thermal comfort was analyzed based on traditional pointwise measuring probes and on the standard ISO 7730. It is revealed that the thermal comfort was significantly improved using the lobed diffuser compared to the conventional one, without increase of pressure drop and sound pressure levels. (C) 2016 Elsevier B.V. All rights reserved.