This paper presents an experimental study on R1234yf flow boiling inside a mini microfin tube with an inner diameter at the fin tip of 2.4 mm. R1234yf is a new refrigerant with an extremely low global warming potential (GWP < 1), proposed as a possible substitute for the common R134a, whose GWP is about 1300. The mass flux was varied between 375 and 940 kg m(-2) s(-1), heat flux from 10 to 50 kW m(-2), and vapor quality from 0.1 to 1. The saturation temperature at the inlet of the test section was kept constant and equal to 30 degrees C. Thewide range of operative test conditions permitted highlighting the effects of mass flux, heat flux, and vapor quality on the thermal and hydraulic behavior during the flowboilingmechanism inside such aminimicrofin tube. The results showthat at lowheat flux the phase-change process is mainly controlled by two-phase forced convection, and at high heat flux by nucleate boiling. The two-phase frictional pressure drop increases with increasing bothmass velocity and vapor quality. Dry-out was observed only at the highest heat flux, at vapor qualities of around 0.94-0.95.