In many applications, the ionic resistance of an ion-exchange membrane shows a strong dependency on the external solution concentration and hydrodynamic environment. It is critical to understand the insights of ion exchange membrane process if its ionic resistance can be simulated accurately. In this paper, we have developed a new model by taking into account both the membrane properties that affect the membrane bulk resistance and hydrodynamic environment that affects the non-ohmic behavior of membrane resistance. The new model not only explains external solution concentration dependency, but also explicitly establishes a relationship between the measured membrane resistance and current density. The modeling results on the direct current (DC) and alternating current (AC) resistance of membranes are compared with experimental data measured under different external solution concentrations and applied current densities. We demonstrate that the model accurately predicts the behaviors of sulfonated polypoly (2,6-dimethyl-1,4-phenylene oxide) membranes and fumasep((R))-FKS and FAS membranes in all cases. The integrative modeling and experimental study provides insights into the ion-exchange membrane synthesis as well as reverse and conventional electrodialysis processes.