Methylcellulose 조성 온도 감응성 졸-젤 유착방지제

김진; 천서영; 신동일; 이창문; 이기영; Jin Kim; Seo Young Cheon; Dong Il Shin; Chang Moon Lee; Ki-Young Lee

Polymer(Korea), Vol.41, No.2, 318-323, March, 2017

DOI10.7317/pk.2017.41.2.318 Export Citation

Methylcellulose 조성 온도 감응성 졸-젤 유착방지제

Adhesion Barrier of Methylcellulose Based Thermo-Responsive Sol-Gel

김진, 천서영, 신동일, 이창문^{1, †}, 이기영 ^{2, †}

전남대학교 신화학소재공학과
¹전남대학교 의공학과
²전남대학교 화학공학부 & ㈜바이오코스모스

Jin Kim, Seo Young Cheon, Dong Il Shin, Chang Moon Lee^{1, †}, and Ki-Young Lee^{2, †}

Department of Advanced Chemicals and Engineering, Chonnam National University, Gwangju 61186, Korea
¹Department of Biomedical Engineering, Chonnam National University, Yeosu 59626, Korea
²School of Chemical Engineering and Biocosmos Co., Chonnam National University, Gwangju 61186, Korea

E-mail:,

초록

유착방지막을 제조하기 위해 methylcellulose(MC)와 xanthan gum(XT) 조성의 온도 감응성 졸-젤을 제조하였다. MC/XT 졸(sol)은 사람의 신체온도(37 °C)에서 1분 안에 젤화(gelation)가 일어나는 것을 보였다. Rat에 온도 감응성 졸-젤을 주입하여 생체적합성 및 생체분해성을 확인하였다. 또한 온도 감응성 졸-젤이 장기 및 조직의 유착방지에 효과가 높은 것을 관찰하였다. 그 결과 MC/XT 졸-젤은 조직 유착방지막의 좋은 후보 물질임을 확인하였다.

Thermo-responsive sol-gel was prepared from methylcellulose (MC) and xanthan gum (XT) for adhesion barrier. The prepared MC/XT sol-gel showed transition temperature and gelation around body temperature (37 °C) within 1 min. In vivo biocompatibility and biodegradability of the MC/XT sol-gel were validated by implantation of the gel in rats. Also, the MC/XT sol-gel was highly effective for the prevention of tissue and organ adhesion. Therefore, the MC/XT sol-gel can be a good candidate material as a tissue adhesion barrier.

Keywords:methylcellulose;xanthan gum;sol-gel;adhesion barrier

[References]

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Gutowska A, Jeong B, Jasionowski M, Anatom. Record., 263, 342 (2001)
Namgung R, Kim WJ, Biomater. Res., 14, 86 (2010)
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Park JK, Nah JW, Choi C, Polym. Korea, 39(3), 480 (2015)
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Kim JK, Won YW, Lim KS, Kim YH, Pharm. Res., 29, 525 (2012)
Kobayashi K, Huang CI, Lodge TP, Macromolecules, 32(21), 7070 (1999)
Sarkar N, Walker LC, Carbohydr. Polym., 27, 177 (1995)
Li L, Shan H, Yue CY, Lam YC, Tam KC, Hu X, Langmuir, 18(20), 7291 (2002)
Elham K, Fariba G, Mohsen T, Maryam S, Iran Polym. J., 22, 785 (2013)
Liu Z, Yao P, Carbohydr. Polym., 132, 490 (2015)
Oh AG, Biomater. Res., 17, 138 (2013)
Kim J, Cho EB, Lee CM, Lee KY, Polym. Korea, 40(2), 306 (2016)

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[2] Gutowska A, Jeong B, Jasionowski M, Anatom. Record., 263, 342 (2001)

[3] Namgung R, Kim WJ, Biomater. Res., 14, 86 (2010)

[4] Klouda L, Mikos AG, Eur. J. Pharm. Biopharm., 68, 34 (2008)

[5] Park JK, Nah JW, Choi C, Polym. Korea, 39(3), 480 (2015)

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[7] Li L, Macromolecules, 35(15), 5990 (2002)

[8] Park JK, Lee KJ, Son DH, Choi C, Jang MK, Nah JW, J. Chitin Chitosan, 16, 45 (2011)

[9] Kim JK, Won YW, Lim KS, Kim YH, Pharm. Res., 29, 525 (2012)

[10] Kobayashi K, Huang CI, Lodge TP, Macromolecules, 32(21), 7070 (1999)

[11] Sarkar N, Walker LC, Carbohydr. Polym., 27, 177 (1995)

[12] Li L, Shan H, Yue CY, Lam YC, Tam KC, Hu X, Langmuir, 18(20), 7291 (2002)

[13] Elham K, Fariba G, Mohsen T, Maryam S, Iran Polym. J., 22, 785 (2013)

[14] Liu Z, Yao P, Carbohydr. Polym., 132, 490 (2015)

[15] Oh AG, Biomater. Res., 17, 138 (2013)

[16] Kim J, Cho EB, Lee CM, Lee KY, Polym. Korea, 40(2), 306 (2016)