화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.48, 56-65, April, 2017
DOI10.1016/j.jiec.2016.12.020  Export Citation
Preparation of gold core-mesoporous iron-oxide shell nanoparticles and their application as dual MR/CT contrast agent in human gastric cancer cells
Aastha Kukreja, Byunghoon Kang, Hyun-Ouk Kim, Eunji Jang1, Hye Young Son1, Yong-Min Huh1, and Seungjoo Haam†
  • a Department of Chemical and Biomolecular Engineering, College of Engineering, Yonsei University, Seoul 120-749, Republic of Korea
  • 1Department of Radiology, College of Medicine, Yonsei University, Seoul 120-749, Republic of Korea
E-mail:
Multifunctional nano-systems are an enticing approach toward the design of nanoparticles with desired characteristics because of interactions between various components of the system. The combination of various imaging modalities often augments the advantages and simultaneously overcomes restrictions encountered by the individual techniques. This report describes the development of multifunctional gold core/iron oxide porous-shell nanoparticles (AuFe NPs) functionalized with matrix metalloproteinase peptide for targeted multi-mode magnetic resonance and computed tomography imaging. This study demonstrates that AuFe NPs simultaneously possess both T2-based contrast effect and X-ray attenuation properties in vitro. The drug loading capacity of porous iron oxide shell is also proposed.
Keywords:Dual imaging;Iron oxide-gold nanoparticles;MR imaging;CT imaging
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