Electrochemical sensor for selective detection of norepinephrine using graphene sheets-gold nanoparticle complex modified electrode

Eun Jung Lee; Jin-Ha Choi; Soong Ho Um; Byung-Keun Oh

Korean Journal of Chemical Engineering, Vol.34, No.4, 1129-1132, April, 2017

DOI10.1007/s11814-016-0363-4 Export Citation

Electrochemical sensor for selective detection of norepinephrine using graphene sheets-gold nanoparticle complex modified electrode

Eun Jung Lee, Jin-Ha Choi, Soong Ho Um¹, and Byung-Keun Oh^†

Department of Chemical & Biomolecular Engineering, Sogang University, Seoul 04107, Korea
¹School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Korea

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Neural diseases, like Alzheimer’s (AD) and Parkinson’s (PD) are widely expanding portions of neurodegenerative diseases, are related to norepinephrine (NE) concentration with proportional correlation. However, quantification of NE is quite difficult because NE coexists with ascorbic acid (AA) and uric acid (UA), which interferes with detecting NE in biological fluid. We fabricated a multi-modified electrode with reduced graphene oxide sheets (GS) and gold nanoparticles (GNPs) for highly selective and sensitive detection of NE. Thus, GS-GNPs modified electrode could enhance the sensitivity for detection of NE, as well as highly sensitive manner with AA. Compared with recent studies, our newly developed sensor appears to have not only a wide detection range (0.2-10 μM), but also superior detection limit (200 nM) in presence of 2000 times higher concentration of AA.

Keywords:Reduced Graphene Oxide Sheets (GS);Gold Nanoparticles (GNPs);Norepinephrine;Electrochemical Sensor

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Yao YI, Ding Y, Ye LS, Xia XH, Carbon, 44, 61 (2006)
Sass JO, Skladal D, Brunner-Krainz M, Metabolic Brain Disease, 14, 67 (1999)
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Yao H, Sun Y, Lin X, Tang Y, Huang L, Anal. Chim., 97, 1217 (2007)
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[2] Suh YH, Checler F, Pharmacol. Rev., 54, 469 (2002)

[3] Grieshaber D, MacKenzie R, Voeroes J, Reimhult E, Sensors, 8, 1400 (2008)

[4] Szantai E, Szilagyi A, Guttman A, Sasvari-Szekely M, Ronai Z, J. Chromatogr. A, 1053, 241 (2004)

[5] Hubbard KE, Wells A, Owens TS, Tagen M, Fraga CH, Stewart CF, Biomed. Chromatogr., 24, 626 (2010)

[6] Chan FL, Chang WY, Kuo LM, Lin CH, Wang SW, Yang YS, Lu MS, J. Micromech. Microeng., 18, 075028 (2008)

[7] Shukla R, Bansal V, Chaudhary M, Basu A, Bhonde RR, Sastry M, Langmuir, 21(23), 10644 (2005)

[8] van Noort D, Mandenius CF, Biosens. Bioelectron., 15, 203 (2000)

[9] Bansal C, Sarkar S, Mishra A, Abraham T, Lemier C, Hahn H, Sci. Mater., 56, 705 (2007)

[10] Mao K, Wu D, Li Y, Ma H, Ni Z, Yu H, Luo C, Wei Q, Du B, Anal. Biochem., 422, 22 (2012)

[11] Li XL, Zhang GY, Bai XD, Sun XM, Wang XR, Wang E, Dai HJ, Nat. Nanotechnol., 3(9), 538 (2008)

[12] Shan C, Yang H, Han D, Zhang Q, Ivaska A, Niu L, Biosens. Bioelectron., 25, 1504 (2010)

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[14] Chen L, Tang Y, Wang K, Liu C, Luo S, Electrochem. Commun., 13, 133 (2011)

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[18] Yao H, Sun Y, Lin X, Tang Y, Huang L, Anal. Chim., 97, 1217 (2007)

[19] Moghaddam HM, Beitollahi H, Int. J. Electrochem. Sci., 6, 6503 (2011)

[20] Ma X, Chen M, Li X, Int. J. Electrochem. Sci., 7, 991 (2012)