The techniques of pulse radiolysis and absorption spectroscopy have been used to determine hydrated electron reaction rate constants with the sulfhydryls mercaptoethanol, 2-aminoethanethiol, cysteine, and penicillamine and the disulfides cystine and penicillamine disulfide, over the pH range 5.0-13.0 in aqueous solution. These values were found to be strongly dependent on the acid-base properties of the sulfhydryl compounds, with the rate constants dependent on the state of protonation of both the amino and mercapto groups, as well as the overall charge in these compounds. Rate constants for reaction of individual sulfhydryl and disulfide species have been determined using literature ionization constants. These values are contrasted to previous literature data.