Glioma is the most common and aggressive primary brain tumor in adults. Long-non coding RNAs (lncRNAs) have been recently shown to play important roles in regulating numerous biological processes both in physiologic and pathologic condition. However, the role of lncRNAs in glioma remains largely unknown. In this study, we firstly found that IncRNA CCND2-AS2 is significantly up regulated in malignant glioma tissues and cell lines. Both loss- and gain-functions assays show that CCND2-AS1 promotes glioma cells proliferation and growth. In addition, we also revealed that highly expressed CCND2-AS1 could enhance Wnt/beta-catenin signaling in glioma. Taken together, our findings revealed a novel IncRNA CCND2-AS1 promotes glioma cell proliferation through Wnt/beta-catenin signaling and CCND2-AS1 might function as a potential novel therapeutic target for the treatment of glioma. (C) 2016 Elsevier Inc. All rights reserved.