The use of CaCO3, FeCl3, and FeOOH as powder sorbents for a plasma-based hydrogen sulfide removal from biogas mixtures was investigated. No plasma-enhanced surface reactions were observed during the processing. However, the high surface area provided by the powders led to an increased deposition of atomic sulfur. The dissociation of H2S in dielectric barrier discharges was found to be effective for gas purification purposes, but limited by the backwards reaction. Medium high gas velocities in a nozzle-like plasma reactor and high retention times in a subsequent expansion vessel thus further improved the desulfurization efficiencies. Furthermore, methane production was observed, whereas the sources could not yet be fully identified.