Although microfluidic solvent extraction (mu SX) is a recent field in separation, its application is still limited to single-channel microfluidic devices. However, the industrial application of microheat exchangers has already proven that parallelization of microchannels is an important tool to increase the specific device efficiency. Hence, in this study, a multichannel system for mu SX is introduced. As a model process, D,L-5-phenylhydantoin was extracted from ethyl acetate into aqueous buffer. By means of different experimental setups, the potential and limitations of membrane-supported multichannel mu SX were investigated. The reactor dimensions perpendicular to flow and transmembrane mass transport are the most challenging factors for the introduced device.