Microreactors of copper foils with microchannels having zeolitic imidazolate framework-8(ZIF-8) films were developed. The films were obtained by direct solvothermal synthesis on the microchannels; they presented micrometric thicknesses and homogeneity, and were activated with highly dispersed silver species. The MOF-based microreactors showed high activity and stability in the carbon monoxide oxidation, which is a benchmark for exothermic gas-phase reactions. The results could bring new perspectives in the development of microreactors for heterogeneous catalytic gas-phase reactions based on other MOF films as supports of active phases. (C) 2016 Elsevier B.V. All rights reserved.