We have studied reactions of thermalized, mass-selected boron oxide (HBnOm+, n = 1-3, m = 1-4) and hydrogenated boron oxide (HBnOm+, n = 1, 2, m = 1-3) ions with HF. Cross sections are reported for each product channel for collision energies ranging from 0.1 to 10 eV (center of mass). On the basis of the observed collision energy dependence, product branching, and effects of hydrogenation, we propose a reaction mechanism where facile reaction occurs only at certain sites on the oxide, most likely at terminal -B=O groups. H atom addition greatly decreases reactivity, apparently by blocking the reactive sites. Our data also point out several significant uncertainties in the literature thermochemistry for B/O/F/H species, and we are able to give some limits on Delta H-f for several molecules.