A solar photoelectro-Fenton (SPEF) plant containing a filter-press FM01-LC flow reactor in series with a compound parabolic collector (CPC) as photoreactor, operating in batch recirculation mode, was simulated using a parametric model. The degradation of 10 dm(3) of solutions of the heterocyclic antibiotic erythromycin (ERY) in 0.050 mol dm(-3) Na2SO4 at pH 3.0 was used for validation. The filter-press reactor contained a platinized titanium plate anode and a graphite-felt cathode that produced H2O2 from the reduction of dissolved oxygen (0.24 mmol dm(-3)). Trials were performed under potentiostatic and galvanostatic conditions with predominance of H2O2 production, minimizing H-2 evolution reaction. The effect of initial catalyst (Fe2+) concentration, current density (j), initial antibiotic concentration as dissolved organic carbon (DOC) and volumetric flow rate on the ERY mineralization was studied. Good agreement between simulations and experimental DOC decays was obtained. Mineralization current efficiencies and specific energy consumptions were also determined. The best performance under galvanostatic conditions was found for 0.225 mmol dm(-3) ERY (100 mg dm(-3) DOC), 0.50 mmol dm(-3) Fe2+, volumetric flow rate of 3.0 dm(3) min(-1) and j(cath) = -0.16 mA cm(-2), reaching 69% mineralization with current efficiency of 75% and specific energy consumption of 0.059 kWh (g DOC)(-1). Six organic by-products were identified by gas chromatography-mass spectrometry, whereas final short-chain carboxylic acids like formic and oxalic acid were detected by ion-exclusion high-performance liquid chromatography. The initial N atom of ERY was predominantly converted into NO3- ion, although NH4+ ion was formed as well. (C) 2017 Elsevier Ltd. All rights reserved.