The half-spin Kagome antiferromagnet is one of the most promising candidates for the realization of a quantum spin liquid state because of its inherent frustration and quantum fluctuations. The search for candidates for quantum spin liquids with novel spin topologies is still a challenge. Herein, we report a new diluted Kagome lattice in Cu-7(TeO3)(2)(SO4)(2)(OH)(6), showing a 9/16-depleted triangle lattice, where the corner-sharing triangle units [Cu-5(OH)(6)O-8] are separated by CuO2(OH)(2). Magnetic measurements show that the title compound does not exhibit long-range antiferromagnetic order down to 2 K, suggesting strong spin frustration with f > 19.