Here we analyze the mixed convective flow of magneto-nanofluid bounded by a vertical stretchable surface considering Brownian motion and thermophoretic diffusion effects. Additionally, the aspects of chemical reaction and activation energy are introduced. Formulation is made through the newly suggested assumption of zero particle flux at the boundary. Equations governing the locally similar flow are tackled through a numerical approach and the influences of involved parameters on the flow fields are displayed graphically. Buoyancy effects resulting from the temperature and concentration differences accelerate the fluid flow in vertical direction. Brownian motion has no influence on the heat flux from stretching wall. Heat flux from the wall diminishes upon increasing the chemical reaction rate constant. Nanoparticle concentration is directly proportional to the activation energy of chemical reaction and the behavior of Brownian motion on nanoparticle concentration is qualitative opposite to that of thermophoretic force. To our knowledge, the nanofluid flow in the regimes of chemical reaction and activation energy is just discussed in this paper. (C) 2017 Elsevier Ltd. All rights reserved.