A novel quantitative methodology to determine the partition coefficients of neutral weak bases is developed. This new electrochemical approach is based on the measurement of the total transferred charge across the oil I water interface under forced hydrodynamic conditions. The complete procedure has been validated by computational simulations and experimental results (Tylosin A). In addition, flow pattern caused inside the electrochemical cell was simulated with computational fluid dynamics using finite element methods and correlated with experimental results obtained by magnetic resonance imaging. (C) 2017 Elsevier B.V. All rights reserved.