Engineering the wettability of zero-dimensional (OD) materials (particles, powders and agglomerates) is a key issue in applications such as dissolution, dispersion, granulation, coating, drying and so on. In the past, the superwettability of 3-dimensional (3D), 2-dimensional (2D) and 1-dimensional (1D) materials has been intensively studied. However, the superwettability of OD materials has received limited attention. It is often investigated as a "collective effect" contributed by many closely packed particles, rather than individual ones. This perspective article reviews the current state of understanding in this area. The definition of superwettable OD materials is first discussed. Some fundamental rules for understanding OD superwettability are proposed. Then, methods for investigating the superwettable state of OD materials are briefly introduced, and the potential applications of superwettable OD materials are described. Finally, the future development of superwettable OD materials is discussed. (C) 2017 Elsevier B.V. All rights reserved.