화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.51, 113-121, July, 2017
DOI10.1016/j.jiec.2017.02.021  Export Citation
Caffeine-loaded gold nanoparticles conjugated with PLA-PEG-PLA copolymer for in vitro cytotoxicity and anti-inflammatory activity
Kamalakannan Reena1, Mani Gajendiran2, 3, †, Muthusamy Prabakaran1, Susaimanickam Arul Antony1, and Kyobum Kim4, †
  • 1PG and Research Department of Chemistry, Presidency College, Chennai 600005, India
  • 2Tissue Engineering and Stem Cell Science Lab, Division of Bioengineering, College of Life Sciences and Bioengineering, Incheon National University,, Incheon 22012, South Korea
  • 3Department of Chemistry, School of Basic Sciences, Vels University (VISTAS), Chennai 600117, India
  • 4Tissue Engineering and Stem Cell Science Lab, Division of Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, South Korea
E-mail:,
The purpose of the study was to develop caffeine-loaded gold nanoparticles (AuNPs) using a poly(lactic acid)-polyethylene glycol-poly(lactic acid) (PLA-PEG-PLA) polymer to enhance the anti-inflammatory activity of caffeine. Caffeine-loaded AuNPs were conjugated to PLA-PEG-PLA copolymer matrix via π-back bond between AuNPs and the ester carbonyl group of the polyester. The π-back bonded ester carbonyl oxygen strongly interacted with the caffeine molecule and exhibited enhanced antiinflammatory activity. The physico-chemical characteristics of the resulting nanoconjugates were evaluated by a series of microscopic, diffraction, and spectroscopic methods. In vitro assays indicated increasing membrane stabilization of red blood cells and enhanced inhibition of protein denaturation.
Keywords:Caffeine;Gold nanoparticles;PLA-PEG-PLA copolymer;In vitro cytotoxicity;Anti-inflammatory activity
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