Structural optimization of rapidly separating microneedles for efficient drug delivery

Dan Dan Zhu; Bo Zhi Chen; Meng Chan He; Xin Dong Guo

Journal of Industrial and Engineering Chemistry, Vol.51, 178-184, July, 2017

DOI10.1016/j.jiec.2017.02.030 Export Citation

Structural optimization of rapidly separating microneedles for efficient drug delivery

Dan Dan Zhu, Bo Zhi Chen, Meng Chan He, and Xin Dong Guo^†

Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China

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Rapidly separating microneedles (RSMNs) arose as an improvement of traditional MNs for the special separable structures. The aim of this study was to investigate various structural parameters contributed to the delivery performance of RSMNs. The experimental results indicated that the optimized RSMNs with 500 μm-long solid PLA MNs, 250 μm-long overlap and 500 μm-long dissolving MNs delivered over 95% of drugs within 30 s. In the in vivo diabetic mice treatment, insulin loaded optimized RSMNs reached approximately the same therapeutic effect on lowering the glucose in blood as injection, significantly better than traditional MNs.

Keywords:Microneedles;Efficiency;Optimized structure;Painless;Drug delivery

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[2] Langer R, Adv. Drug Deliv. Rev., 56, 557 (2004)

[3] Prausnitz MR, Adv. Drug Deliv. Rev., 56, 581 (2004)

[4] Williams AC, Barry BW, Adv. Drug Deliv. Rev., 56, 603 (2004)

[5] Kersten G, Hirschberg H, Expert Opin. Drug Deliv., 4, 459 (2007)

[6] Garland MJ, Migalska K, Mazlelaa T, Mahmood T, Raghu T, Singh R, Expert Rev. Med. Devices, 8, 459 (2011)

[7] Ling MH, Chen MC, Acta Biomater., 9, 8952 (2013)

[8] Ito Y, Hasegawa R, Fukushima K, Sugioka N, Takada K, Biol. Pharm. Bull., 33, 683 (2010)

[9] Song JM, Kim YC, Barlow PG, Hossain MJ, Park KM, Donis RO, Antivir. Res, 88, 244 (2010)

[10] Quan FS, Kim YC, Song JM, Hwang HS, Compans RW, Prausnitz MR, Clin. Vaccine Immunol., 20, 1433 (2013)

[11] Kim YC, Oh KH, Edelhauser HF, Prausnitz MR, Eur. J. Pharm. Biopharm., 95, 398 (2015)

[12] Miller MA, Pisani E, Bull. W. H. O., 77, 808 (1999)

[13] Simonsen L, Kane A, Lloyd J, Zaffran M, Kane M, Bull. W. H. O., 77, 789 (1999)

[14] Alarcon JB, Hartley AW, Harvey NG, Mikszta JA, Clin. Vaccine Immunol., 14, 375 (2007)

[15] Pierre MBR, Rossetti FC, Curr. Drug Targets, 15, 281 (2014)

[16] Wu F, Yang SX, Yuan WE, Jin T, Curr. Pharm. Biotechnol., 13, 1292 (2012)

[17] Ito Y, Kashiwara S, Fukushima K, Takada K, Drug. Dev. Ind. Pharm., 37, 1387 (2011)

[18] Fukushima K, Ise A, Morita H, Hasegawa R, Ito Y, Sugioka N, Pharm. Res., 28, 7 (2011)

[19] Lee JW, Choi SO, Felner EI, Prausnitz MR, Small, 7, 531 (2011)

[20] Lee IC, He JS, Tsai MT, Lin KC, J. Mat. Chem. B, 3, 276 (2015)

[21] Ito Y, Hirono M, Fukushima K, Sugioka N, Takada K, Int. J. Pharm., 436, 387 (2012)

[22] Lee SG, Jeong JH, Lee KM, Jeong KH, Yang H, Kim M, Int. J. Nanomed., 9, 289 (2014)

[23] Chu LY, Prausnitz MR, J. Control. Release, 149, 242 (2011)

[24] Choi HJ, Yoo DG, Bondy BJ, Quan FS, Compans RW, Kang SM, Biomaterials, 33, 3756 (2012)

[25] Ma YZ, Boese SE, Luo Z, Nitin N, Gill HS, Biomed. Microdevices, 17, 44 (2015)

[26] Gill HS, Prausnitz MR, J. Control. Release, 117, 227 (2007)

[27] Cormier M, Johnson B, Ameri M, Nyam K, Libiran L, Zhang DD, J. Control. Release, 97, 503 (2004)

[28] Zhu DD, Wang QL, Liu XB, Guo XD, Acta Biomater., 41, 312 (2016)

[29] Gupta J, Park SS, Bondy B, Felner EI, Prausnitz MR, Biomaterials, 32, 6823 (2011)

[30] Yan GA, Warner KS, Zhang J, Sharma S, Gale BK, Int. J. Pharm., 391, 7 (2010)

[31] Wang QL, Zhu DD, Chen Y, Guo XD, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 65 (2016)