화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.52, 128-137, August, 2017
DOI10.1016/j.jiec.2017.03.034  Export Citation
Preparation and characterization of pH-sensitive alginate-g-poly(Nvinyl-2-pyrrolidone)/gelatin blend beads
Murat Inal, Nuran Işıklan1, †, and Mustafa Yigitoglu
  • Department of Bioengineering, Faculty of Engineering, Kırıkkale University, 71450 Yahşihan, Kırıkkale, Turkey
  • 1Department of Chemistry, Faculty of Arts and Sciences, Kırıkkale University, 71450 Yahşihan, Kırıkkale, Turkey
E-mail:
In this study, pH-sensitive alginate-g-poly(N-vinyl-2-pyrrolidone)/gelatin (SA-g-PVP/Gel) blend beads were produced as controlled release system. Structural features of the SA-g-PVP/Gel beads were characterized by FTIR, X-RD, DSC, SEM and mercury intrusion-porosimetry. In vitro nifedipine (NFD) release was investigated at pH 1.2 for 2 h and followed by immersing at pH 7.4 for 6 h. Effects of diverse parameters such as grafting of PVP, copolymer/gelatin blend ratio, concentration of cross linker and drug amount on the release of NFD were investigated. The NFD release from SA-g-PVP/Gel beads demonstrated pH-sensitivity of drug release. Cytotoxicity experiments of SA-g-PVP and SA g PVP/Gel beads displayed their biocompatible character.
Keywords:Graft copolymer;Polymeric blend;Sodium alginate;Gelatin;Poly(N-vinyl-2-pyrrolidone)
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