In this present work, the CO2 absorption performance of aqueous 1-diethylamino-2-propanol (1DEA2P) solution was studied with respect to CO2 equilibrium solubility, absorption kinetics, and absorption heat. The equilibrium solubility of CO2 in 2M 1DEA2P solution was measured over the temperature range from 298 to 333 K and CO2 partial pressure range from 8 to101 kPa. The absorption kinetics data were developed and analyzed using the base-catalyzed hydration mechanism and artificial neural network models (radial basis function neural network [RBFNN] and back-propagation neural network [BPNN] models) with an acceptable absolute average deviation of 10% for base-catalyzed hydration mechanism, 2.6% for RBFNN model and 1.77% for BPNN model, respectively. The CO2 absorption heat of 1DEA2P was estimated to be -43.6 kJ/mol. In addition, the ions (1DEA2P, 1DEA2PH(+),HCO3-, CO32-) speciation plots of the 1DEA2P-CO2-H2O system were developed to further understand the reaction process of 1DEA2P with CO2. Based on a comparison with conventional amines (e.g., MEA, DEA, MDEA) and alternative amines (i.e., 1DMA2P and 4-(diethylamino)-2-butanol [DEAB]), 1DEA2P exhibited good performance with respect to CO2 equilibrium solubility, reaction kinetics, and CO2 absorption heat. Meanwhile, the overall evaluation of 1DEA2P for application in CCS in terms of absorption and desorption is presented, giving helpful information for the screening of these novel amines. (c) 2017 American Institute of Chemical Engineers AIChE J, 63: 2694-2704, 2017