A quantitative structure-property relationship (QSPR) treatment of the normal boiling points was performed for a structurally wide variety of organic compounds using the CODESSA (comprehensive descriptors for structural and statistical analysis) technique. A highly significant two-parameter correlation (R(2) = 0.9544, s = 16.2 K) employs just two molecular parameters, a bulk cohesiveness descriptor, G(I)(1/3), and the area-weighted surface charge of the hydrogen-bonding donor atom(s) in the molecule. A more refined QSPR model (with R(2) = 0.9732 and s = 12.4 K) includes, in addition, the most negative atomic partial charge acid the number of the chlorine atoms in the molecule. The four-parameter equation offers an average predicted error of 2.3% for a standard set of compounds with an average experimental error of 2.1%. The QSPR equations developed allow remarkably accurate predictions of the normal boiling points for a number of simple inorganic compounds, including water.