Ultrasonication is frequently used to promote crystallization and chemical reactions, with many papers reporting the effects of ultrasonic parameters. High-speed pressure inducers (aka pinducers) and signal processing are used here to gain insights into the spatial localization of energy dissipation that occurs during ultrasonication, facilitating a design that allows ultrasonication to be spatially localized inside a tube, without requiring that the probe directly contact the solution. The fluid pressure measured inside of a flexible silicone tube pressed against an ultrasonic probe is observed to move between nearly constant amplitude oscillations to variable shape and amplitude waveforms that deviate significantly from being periodic. Ultrasonic power is transferred to the fluid inside the tube, generating a wide frequency range including via bubble oscillations. Discrete Fourier Transform analysis indicates complex interactions within the experimental system, in addition to the energy transferred inside the tubing at the expected ultrasonic source frequency. The total acoustic intensity decays exponentially with distance from the zone, dropping by more than two orders-of-magnitude for each 1 cm increase in distance. The pinducer data analyses guide the design of an experimental setup in which crystals nucleate within fluid inside the zone in the tube, right under the ultrasonic probe.