The application of a microreactor system for the continuous synthesis of nanostructured Co3O4@SiO2 core-shell particles was investigated and compared to the standard lab experiment in batch operation. TEM images reveal that the synthesis of nanostructured core-shell particles in a laminar-flow reactor is generally possible. However, the particle size distribution for both SiO2 and core-shell particles synthesized continuously in a microreactor is broader, probably due to axial dispersion under laminar-flow conditions.