The influence of two differently cross-linked polyacrylate particles on CO2 hydrate formation was investigated. A series of up-scaling experiments from small (high-pressure differential scanning calorimetry, HP-DSC) over medium (glass reactor) to large scale (HP-reactor) was carried out. It was found out that there is a low influence on the induction time, which is an essential key parameter of the hydrate formation. The results show the same trends: with a low degree of cross-linker used in low concentration CO2 hydrate formation could be enhanced.