Chemistry Letters, Vol.46, No.8, 1119-1121, 2017
Self-assembly of a Peptide [2]Catenane through Omega-Loop Folding
In this work, a peptide [2]catenane was created by exploiting the strong tendency of the Pro-Gly-Pro (PGP) sequence to fold into an Omega-loop. Ditopic heptapeptide ligand 1, which includes the PGP sequence, formed peptide [2] catenane 2 on complexation with Ag+. Moreover, addition/removal of Na+ triggered a reversible structural change between 2 and twisted macrocycle 3.