A new series of amino perfluoroalkanesulfonamide compounds derived from diarylprolinols has been developed and found to be efficient catalysts for the reaction of ethyl glyoxylate with 4-(benzyloxy) butanal. The aldol product, obtained in good yield with excellent enantio-and diastereomeric excess, is an intermediate for the synthesis of bis-THF alcohol, which is a commonly used unit in the design of HIV protease inhibitors such as Darunavir.