This study investigates the performance of a new vacuum spray flash desalinator, a core component of the open water cycle in a discharge thermal energy combined desalination (DTECD) technology using theoretical and experimental techniques. The feedwater contains 3.5wt% of NaCl while the inlet temperature range can vary over a range of 55 degrees C to 75 degrees C based on the low temperature utilised in the DTECD system. In order to design an efficient desalinator, physical aspects of the proposed vacuum spray flash evaporation (VSFE) should be studied. Thus, an experimental study was undertaken to verify the theoretical evaporation rate and centreline temperature data. The proposed desalinator was modelled using a CFD model implemented in the available package ANSYS FLUENT 16.2 and some results are compared with a thermodynamic model embedded in ASPEN/HYSY 8.0. It was observed that the defined thermodynamic models based on vapor-liquid equilibrium in the Aspen and Fluent can predict the evaporation rate with the average errors of 5% and 17%, respectively. Moreover, discrete phase model (DPM) approach can analyse the thermo-fluid field in the desalinator with acceptable accuracy about 9%. Droplets size, velocity, temperature and concentration profiles are predicted and the underlying physics are discussed regarding the VSFE geometry. (C) 2017 Published by Elsevier B.V.