Direct contact membrane distillation (DCMD) has immense potential in the desalination of highly saline waste-waters where reverse osmosis is not feasible. This study evaluated the potential of DCMD for treatment of produced water generated during extraction of natural gas from unconventional (shale) reservoirs. Exhaust stream from Natural Gas Compressor Station (NG CS), which has been identified as a potential waste heat source, can be used to operate DCMD thereby providing economically viable option to treat high salinity produced water. An ASPEN Plus simulation of DCMD for the desalination of produced/saline water was developed in this study and calibrated using laboratory-scale experiments. This model was used to optimize the design and operation of large scale systems and estimate energy requirements of the DCMD process. The concept of minimum temperature approach used in heat exchanger design was applied to determine the optimum membrane area for large scale DCMD plants. Energy analysis revealed that the waste heat available from NG CS is sufficient to concentrate all the produced water generated in Pennsylvania to 30 wt% regardless of its initial salinity. (C) 2017 Elsevier B.V. All rights reserved.