The current paper presents the main steps in the design of large-scale photovoltaic (PV) power generation plants in University campuses towards their energy independence. As an example is used the campus of the Technical University of Crete as a base case to describe the design. Today the insular power system of Crete is based on oil fuel by 75%. Solar electricity is designed and discussed in this report. For this scope, the energy consumption figures of the buildings within the campus are analyzed. In parallel, a feasibility study of the PV energy generation is conducted revealing their potential contributions and applicability. The resultant electrical energy generation design satisfies the project objective by utilizing alternative energy sources and reducing the greenhouse gas emissions of the campus. The results obtained are satisfactory being both technically and economically feasible. To conclude, these designs proposed in this project can be the first steps towards a 100% green energy campus and get even more tempting with relevant technological improvements in the future. (C) 2017 Elsevier B.V. All rights reserved.