Biofuels have the most potential as an alternative to "fossil fuels and overcoming global warming, which has become one of the most serious environmental issues over the past few decades. As the world confronts food shortages due to an increase in world population, the development of biofuels from inedible lignocellulosic feedstock may be more sustainable in the long term. Inspired by the NREL conventional process, this paper proposes a novel heat-integrated and intensified biorefinery design for cellulosic ethanol production from lignocellulosic biomass. For the preconcentration section, heat pump assisted distillation and double-effect heat integration were evaluated, while a combination of heat-integrated technique and intensified technique, extractive dividing wall column (EDWC), was applied to enhance the process energy and cost efficiency for the purification section. A biosolvent, glycerol, which can be produced from biodiesel production, was used as the extracting solvent in an EDWC to obtain a high degree of integration in a biorefinery context. All configuration alternatives were simulated rigorously using Aspen Plus were based on the energy requirements, total annual costs (TAC), and total carbon dioxide emissions (TCE). In addition, the structure of the EDWC was optimized using the reliable response surface method, which was carried out using Minitab statistical software. The simulation results showed that the proposed heat-integrated and intensified process can save up to 47.6% and 56.9% of the TAC and TCE for the purification section, respectively, compared to the conventional purification process. (C) 2016 Elsevier Ltd. All rights reserved.