Silver nanoparticles are known especially because their antimicrobial properties can be used as conductive ink or adhesives for different electronics in compliance with their unique electronic and optical properties. As they are well-known, these practices require smaller nanoparticle formation. A response surface methodology based desirability function approach has been first applied to achieve the desired size of silver nanoparticles with the green synthesis methods. It is notable that the improvement rates at 7.9% by the mean of particle size distribution in AgNPs manufacturing process have been obtained with the utilization of utilizing the proposed methodology. When these results are evaluated, it can be seen that an 89.3% lower standard deviation has been obtained in comparison with the studies in literature. The results also show that the minimization of the nanosilver production variance should be performed to obtain the high quality and large scale manufacturing process.