The two novel cluster organic frameworks based on heterometallic supertetrahedral cluster secondary building units (SBUs) [Cd4Cu6(L)(4)(Ac)(7)(H2O)(4)](Ac)center dot 7H(2)O (1) and [Mn4Cu6(L)(4)(Ac)(4.5)(H2O)(9)]CuCN(Ac)(3.5)center dot H2O (2), where H3L = 2-(hydroxymethyl)-2-(pyridin-4-y1)-1,3-propanediol and Ac = CH3COO-, have been prepared under solvothermal conditions. 1 and 2 are the first cases of cluster organic frameworks containing Cd-Cu/Mn-Cu heterometallic super-tetrahedral cluster SBUs. Furthermore, 1 and 2 show an integration of magnetic properties and adsorption properties from both the heterometallic cluster secondary building units and the framework in a porous material.