Here peristalsis of Sisko nanoliquid with gyrotactic microorganism in a curved channel is investigated. Channel boundaries comprises the wall properties and second order slip conditions for velocity. Consideration of Newtonian heat, mass and gyrotactic microorganisms aspects characterizes the heat, mass and motile density transfer processes. Flow formulation is established utilizing constitutive relations of Sisko fluid. Lubrication theory is employed for the simplification of governing expressions. Further numerical solution is carried out for velocity, temperature, concentration and motile density gyrotactic microorganisms. The numerical solution is justified through graphical results. Graphical discussion determined that velocity has opposite behavior for first and second order velocity slip parameters. Interestingly Sisko fluid parameter has opposite impact on velocity for both shear thinning and shear thickening cases. It is seen that temperature enhances for Newtonian heating whereas concentration and gyrotactic microorganism reduces for Newtonian mass and Newtonian gyrotactic microorganisms. (C) 2017 Elsevier Ltd. All rights reserved.