화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Journal of Chemical Engineering, Vol.34, No.11, 3017-3027, November, 2017
DOI10.1007/s11814-017-0201-3  Export Citation
Statistical optimization of curcumin nanosuspension through liquid anti-solvent precipitation (LASP) process in a microfluidic platform: Box-Behnken design approach
Masoud Rahimi, Peyvand Valeh-e-Sheyda1, and Hamed Rashidi1, †
  • CFD Research Center, Chemical Engineering Department, Razi University, Kermanshah, Iran
  • 1Chemical Engineering Department, Kermanshah University of Technology, Kermanshah, Iran
E-mail:
The paper deals with the development and optimization of curcumin nanosuspension by solvent/anti-solvent precipitation method in a microfluidic platform. A three-level Box-Behnken design was applied as an optimizing technique to investigate the effect of three independent operating variables, namely, volume ratios of anti-solvent to solvent, flow rate of drug solution, and curcumin concentration on the preferred response. In presence of PVP as the stabilizer, a nano-curcumin suspension was obtained in the range of 62-335nm. Analysis of variance showed that the variables with the highest effect were the linear effects of the anti-solvent to solvent ratio, and its corresponding squared term. Applying response surface methodology, curcumin nanosuspension with average size of 63.12 nm can be obtained under optimum condition As: S=15, solvent flow rate of 1.0mL/min and curcumin ethanolic concentration of 5.0mg/mL. The prepared nanoparticles were further characterized by infrared spectroscopy, scanning electron microscopy, and X-ray diffraction tests.
Keywords:Anti-solvent;Box-Behnken;Curcumin;Microfluidics;Particle Size;Precipitation
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