화학공학소재연구정보센터
AIChE Journal, Vol.63, No.9, 3743-3755, 2017
Scaling Inter-Tablet Coating Variability in a Horizontal Rotating Drum
This study investigates how the drum-to-particle diameter ratio (D/d) affects the surface speed and interparticle coating variability in geometrically similar coaters. Discrete element method simulations were used to model particle movement in different-sized, cylindrical drums with identical particle diameters, Froude numbers, fill volume fractions, and spray characteristics. The dimensionless streamwise surface speed profiles become increasingly symmetric as D/d increases, with the maximum speed increasing with D/d. The relationship between the maximum dimensionless speed and D/d is fit well with a power-law expression. Interparticle coating variability decreases with the square root of the number of drum revolutions after a sufficiently large number of drum revolutions. Increasing D/d increases, in a logarithmic manner, the number of drum revolutions required to reach a given degree of coating variability. A similar logarithmic coating variability trend was observed in simulations using almond-shaped pharmaceutical tablets, suggesting that the trend is independent of tablet shape. (c) 2017 American Institute of Chemical Engineers AIChE