An integral microchannel device is generally formed by lamination of multiple microchannel sheets. Uniform velocity distribution among the microchannels in each sheet shows a large influence on the device's performance. The effects of microchannel and manifold structure on the velocity uniformity in each sheet with different structural parameters under parallel and series laminated structures are investigated. For the laminated-sheet structure where each sheet has the same structural parameters, a more uniform velocity distribution exists as compared to where the structural parameters are different. There exists a direct correlation between the velocity values in each sheet and structural parameters, whereas an inverse correlation is found under series laminated structure.