Nickel catalysts prepared on high-surface-area mesoporous MgSiO3 were synthesized and applied in methanation of CO2. N-2 adsorption analysis confirmed the presence of the mesoporous structure on the synthesized samples and revealed that the increase in nickel content resulted in a shift of the pore size distributions to smaller pore sizes. Temperature-programmed reduction analysis illustrated an improvement in reducibility of the catalysts by a higher nickel content. Catalytic results indicated enhanced CO2 conversion with the increase in nickel percentage up to 15 wt%. The catalysts with higher percentage of nickel provided lower CO2 conversion and CH4 selectivity. The %15Ni/MgSiO3 catalyst exhibited high catalytic stability under optimized conditions.