The importance of interference effects in electron scattering from complex molecular targets is demonstrated theoretically by an exemplificative case study of small water clusters. Interference contributions arising from all the scattering centres in the target lead to an increase of the elastic differential cross sections at small scattering angles and to the appearance of prominent minima in the cross sections of threedimensional isomers which resemble structural properties of bulk water. The phenomena which are absent for isolated water molecules but emerge for small water clusters may help to better understand electron-driven processes in condensed aqueous media. (C) 2017 Elsevier B.V. All rights reserved.