The application of orodispersible films (ODFs) as carrier for drug nanoparticles was discovered a few years ago. Poorly water-soluble drugs are milled to nanosuspensions to improve their bioavailability. During the manufacturing process they are embedded into a polymer matrix or loaded on the surface of drug-free ODF templates. The particle size of the particles released from the ODF was measured when redispersed in water. A preservation of the drug particle sizes could be achieved for both investigated ODF types when an adequate amount of matrix material is added to prevent agglomeration during the drying process.