As one of themain reasons causing leakage heat load in a refrigerator, mass and heat transfer through refrigerator door seal is of great importance to be studied. In this paper, amodel is presented for numerical simulation of mass and heat transfer process through refrigerator door seal, and an experiment apparatus is designed and set up as well for comparison. A two-dimensional model and tracer gas method are used in simulation and experiment, respectively. It can be found that the relative deviations of air infiltration rate between the simulated results and experimental results were less than 1%, and the temperature difference errors at two special points of the door sealwere less than 2.03 degrees C. In conclusion, the simulated results are in good agreement with the experimental results. This paper initially sets up a model that can accurately simulate the heat and mass transfer through the refrigerator door seal, and the model can be used in refrigerator door seal optimization research in the follow-up study. (C) 2017 The Chemical Industry and Engineering Society of China, and Chemical Industry Press. All rights reserved.